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Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community.

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Daily briefing: Are we about to face a ‘super’ El Niño?
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Nature, Published online: 15 May 2026; doi:10.1038/d41586-026-01601-w

The strength of an upcoming El Niño weather pattern is still up in the air — for now. Plus, almost half of lab-mouse strains aren’t what scientists think they are and the hunt for new antibiotics in a graveyard.
https://www.nature.com/articles/d41586-026-01601-w
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Serebral
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Nature, Published online: 15 May 2026; doi:10.1038/d41586-026-01083-w

Forging connections.
https://www.nature.com/articles/d41586-026-01083-w
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Daily briefing: Around seven hours of sleep slows biological ageing
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Nature, Published online: 14 May 2026; doi:10.1038/d41586-026-01578-6

Between six and eight hours of sleep each day seems to be a ‘sweet spot’ for preventing disease. Plus, unexpected interbreeding between Denisovans and Homo erectus, and how the look of antibiotics could be driving antimicrobial resistance.
https://www.nature.com/articles/d41586-026-01578-6
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Protective maternal gut instincts
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Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01322-0

Pregnancy poses many challenges, including protecting against infection and increased nutritional demands. Pregnancy-associated gut changes offer some help.
https://www.nature.com/articles/d41586-026-01322-0
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State media control shapes LLM behaviour by influencing training data
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Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01486-9

State control of the media is shown to alter the training data of large language models (LLMs) through its impact on the information environment. This has a substantial effect on the output of LLMs, with states rated more favourably in their own language when they have tighter media control.
https://www.nature.com/articles/d41586-026-01486-9
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Can AI tools assess coding assignments?
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Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01139-x

Yulu Hou and her partner experimented with using ChatGPT to automate marking of undergraduate assignments. Here’s what they learnt.
https://www.nature.com/articles/d41586-026-01139-x
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Growth charts reveal how the brain’s ‘communication highways’ change throughout life
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Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01318-w

Studies of white matter — the tissue used for communication between brain regions — have revealed substantial changes in people with neurological diseases and disorders. The creation of white-matter brain charts enables individual deviations from the typical structure to be assessed using magnetic resonance imaging (MRI) brain scans.
https://www.nature.com/articles/d41586-026-01318-w
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Fast and furious: the gaseous outflows of quasars in the early Universe were extreme
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Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01485-w

Observations from the James Webb Space Telescope reveal that extremely fast, galaxy-scale outflows from luminous objects called quasars were much more frequent, and on average more powerful, about one billion years after the Big Bang than at later cosmic epochs. These outflows could easily escape their host galaxies and regulate the evolution of early massive galaxies.
https://www.nature.com/articles/d41586-026-01485-w
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White matter micro- and macrostructure brain charts for the human lifespan
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10454-2

Integration of data representing 35,120 brain scans from diverse global studies enables construction of reference charts that define normative microstructural and macrostructural properties across the human lifespan for research and clinical diagnosis.
https://www.nature.com/articles/s41586-026-10454-2
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A synaptic locus of song learning
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10510-x

Combining a computational framework and optogenetic and chemogenetic manipulations within and downstream of the cortico-basal ganglia circuit identifies the specific cortico-basal ganglia synapses that drive the acquisition and expression of rapid vocal changes during juvenile song learning.
https://www.nature.com/articles/s41586-026-10510-x
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Obesity rise plateaus in developed nations and accelerates in developing nations
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10383-0

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.
https://www.nature.com/articles/s41586-026-10383-0
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Sleep chart of biological ageing clocks in middle and late life
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10524-5

A cross-organ, multi-omics U-shaped relationship between sleep duration and biological ageing clocks highlights the potential of sleep optimization to promote healthy ageing, lower disease risk and extend longevity.
https://www.nature.com/articles/s41586-026-10524-5
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Mesoscale atomic engineering in a crystal lattice
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10431-9

Electron-beam control enables deterministic placement of tens of thousands of atomic defects in three-dimensional crystals, creating stable, programmable artificial matter for scalable quantum and nanoscale technologies.
https://www.nature.com/articles/s41586-026-10431-9
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SNOR promotes translation restart after dormancy
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10530-7

High-resolution in situ cryo-electron tomography in Schizosaccharomyces pombe identifies SNOR protein, which binds to ribosomes during dormancy induced by glucose depletion, priming them for rapid reactivation of protein synthesis upon glucose repletion.
https://www.nature.com/articles/s41586-026-10530-7
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Ecotypes of triple-negative breast cancer in response to chemotherapy
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10469-9

Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are associated with a good response to neoadjuvant chemotherapy.
https://www.nature.com/articles/s41586-026-10469-9
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Twenty-first century emergence of alpine fire in Central African mountains
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10511-w

A twenty-first century fire is shown to be the first to have affected a high-elevation region in the central African mountains in the past 12,000 years, and previous burning at mid-elevations highlights the potential role of humans in transforming Afromontane ecosystems.
https://www.nature.com/articles/s41586-026-10511-w
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Enamel proteins from six <i>Homo erectus</i> specimens across China
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10478-8

Palaeoproteomic analysis of ancient enamel proteins extracted from Middle Pleistocene Homo erectus specimens from the Zhoukoudian, Hexian and Sunjiadong sites in China suggests that they are a new genetic monogroup, and super-archaic introgression in Denisovans is likely to have originated from H. erectus.
https://www.nature.com/articles/s41586-026-10478-8
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State media control influences large language models
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10506-7

Government-controlled media influences the output of large language models via their training data, and models queried in the languages of countries with lower media freedom show a stronger pro-regime valence than models queried in the languages of countries with higher media freedom.
https://www.nature.com/articles/s41586-026-10506-7
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Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10494-8

Single-cell transcriptomics combined with morphological and ecological data show that the rapid evolutionary radiation of cichlid fishes in Lake Tanganyika was accompanied by dietary specialization across multiple layers of biological organization.
https://www.nature.com/articles/s41586-026-10494-8
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Efficient robot navigation inspired by honeybee learning flights
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Nature, Published online: 13 May 2026; doi:10.1038/s41586-026-10461-3

A highly efficient navigation strategy taking inspiration from the visual learning flights of honeybees is described, which enables drones to quickly return from longer flights by means of path integration and uses a neural network as a view memory to reach the home location.
https://www.nature.com/articles/s41586-026-10461-3
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Red-light therapy is all the rage — does it work?
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Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01547-z

There are a multitude of red-light emitting consumer goods, but do they really do anything for your health? We look at the science behind the hype — plus, the increasing levels of obesity in lower-income countries.
https://www.nature.com/articles/d41586-026-01547-z
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The hunt for the next antibiotics
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Nature, Published online: 13 May 2026; doi:10.1038/d41586-026-01424-9

To battle antibiotic resistance, researchers are leaving no stone unturned, looking at folk traditions and harnessing AI to find new antibiotics.
https://www.nature.com/articles/d41586-026-01424-9
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Daily briefing: Why humans sleep so much less than other apes
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Nature, Published online: 11 May 2026; doi:10.1038/d41586-026-01526-4

Why, if sleep has so many benefits, humans as a species sleep so little. Plus, universities attempt to save a world-leading weather and climate research lab in Colorado, and Elsevier has joined a class-action lawsuit against Meta.
https://www.nature.com/articles/d41586-026-01526-4
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Male sex hormone loss aids brain tumour growth
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Nature, Published online: 06 May 2026; doi:10.1038/d41586-026-01159-7

Depletion of sex hormones that enable male development induces neuroinflammation that disrupts hormonal signalling and immune responses against brain tumours.
https://www.nature.com/articles/d41586-026-01159-7
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TikTok’s algorithm systematically skewed to the right during the 2024 US elections
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Nature, Published online: 06 May 2026; doi:10.1038/d41586-026-01314-0

An audit of TikTok’s recommendation algorithm using hundreds of automated ‘bot’ accounts during the 2024 US presidential election finds that the ‘For You’ feed of the platform steered users towards Republican-aligned political content, regardless of their initial political leanings.
https://www.nature.com/articles/d41586-026-01314-0
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Relativistic plasmas open a route to extreme optical fields
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Nature, Published online: 06 May 2026; doi:10.1038/d41586-026-01311-3

By precisely shaping the leading edge of ultrafast high-power laser pulses, bright ‘harmonic’ radiation has been generated with great efficiency from plasma oscillating at almost the speed of light. This long-sought regime removes a key barrier to the production of extremely intense electromagnetic fields for applications such as compact particle acceleration, attosecond science and strong-field physics.
https://www.nature.com/articles/d41586-026-01311-3
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25 years of chemistry that simply clicks
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Nature, Published online: 06 May 2026; doi:10.1038/d41586-026-01155-x

When the concept of ‘click’ chemistry — highly effective and specific reactions — was first reported, some dismissed it as a gimmick. But it has transformed many fields of research.
https://www.nature.com/articles/d41586-026-01155-x
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Towards disentangling human-induced drivers of precipitation trends from naturally occurring ones
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Nature, Published online: 06 May 2026; doi:10.1038/d41586-026-01419-6

Combining climate models with statistical learning allows an assessment of the relative contributions of different factors to trends in winter precipitation at mid-latitudes. Thermodynamic (non-circulation-related) effects are mostly consistent between models and observations, but whether circulation-related changes are forced or unforced remains unclear.
https://www.nature.com/articles/d41586-026-01419-6
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The lights are out but someone’s home: sensory processing in anaesthetized human brains
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Nature, Published online: 06 May 2026; doi:10.1038/d41586-026-01310-4

Detailed neural recordings were made from a brain structure called the hippocampus in unconscious anaesthetized people. Neuronal activity responded to ‘oddballs’ in a series of auditory tones, encoded complex meaning-related properties of language and could even predict upcoming words in a heard phrase.
https://www.nature.com/articles/d41586-026-01310-4
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Origin story
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Nature, Published online: 06 May 2026; doi:10.1038/d41586-026-01077-8

Plans for expansion.
https://www.nature.com/articles/d41586-026-01077-8
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Multiplexed magnetic resonance imaging
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Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10475-x

A new approach to magnetic resonance imaging, ‘multiplexed magnetic resonance imaging’, is reported, which enables high-resolution simultaneous multiparametric mapping of multiple molecules in standard clinical settings.
https://www.nature.com/articles/s41586-026-10475-x
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A brain reward circuit inhibited by next-generation weight-loss drugs in mice
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Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10444-4

Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implications for how these orally delivered weight-loss drugs engage brain reward circuits.
https://www.nature.com/articles/s41586-026-10444-4
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Molecular skeleton programming of premediators in sulfur electrochemistry
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Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10505-8

A potential premediator, 2-chloropyrimidine, could be a model material for molecular skeleton design enabling lithium–sulfur batteries to achieve a strong average capacity retention and help design functional molecules in broader organic chemical spaces.
https://www.nature.com/articles/s41586-026-10505-8
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HIV-1 signalling remodels nuclear pores to licence infection
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Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10453-3

HIV-1 capsid nuclear import at the nuclear pore complex is a bottleneck to resting T cell infection, but HIV-1 overcomes this by triggering receptor-mediated signalling during cell–cell spread to drive nuclear import and licence infection.
https://www.nature.com/articles/s41586-026-10453-3
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Steric hindrance of antibody binding in an Omicron spike fusion intermediate
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Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10462-2

The SARS-CoV-2 Omicron variant escapes neutralization by antibodies targeting the pan-coronavirus epitope in a spike fusion intermediate via steric hindrance, but reducing the antibody size overcomes this barrier and expands its range of accessible targets.
https://www.nature.com/articles/s41586-026-10462-2
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Non-invasive profiling of the tumour microenvironment with spatial ecotypes
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Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10452-4

Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via liquid biopsy and used to profile individual cancers and target treatments.
https://www.nature.com/articles/s41586-026-10452-4
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Foreshock-induced slip transients set mainshock nucleation timing
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Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10497-5

Analysis of laboratory experiments using a rate-and-state-based Griffith-like rupture framework shows that foreshocks can regulate mainshock nucleation timing, with larger foreshocks generating higher transient sliding velocities and triggering a more rapid transition to dynamic rupture.
https://www.nature.com/articles/s41586-026-10497-5
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Electrocaloric effects across room temperature in multilayer capacitors
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Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10492-w

Multilayer capacitors comprising a solid solution of two electrocaloric materials PbSc0.5Ta0.5O3 and PbMg0.5W0.5O3 are shown to maintain high B-site order and latent heat without needing an energetically expensive anneal, enabling efficient refrigeration across room temperature.
https://www.nature.com/articles/s41586-026-10492-w
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RNA-triggered cell killing with CRISPR–Cas12a2
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Nature, Published online: 06 May 2026; doi:10.1038/s41586-026-10466-y

Cas12a2 enables RNA-triggered, sequence-specific killing of eukaryotic cells via widespread DNA shredding, allowing selective elimination of cells on the basis of gene expression, including virus-infected or mutation-bearing cells.
https://www.nature.com/articles/s41586-026-10466-y
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Anaesthetized brains can still process podcasts
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Nature, Published online: 06 May 2026; doi:10.1038/d41586-026-01480-1

Neuronal recordings taken during surgery reveal that the brain can learn even when unconscious — plus, the electrical test that can determine a cup of coffee’s strength.
https://www.nature.com/articles/d41586-026-01480-1
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