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Research progress on the impact of humidification therapy on mucociliary clearance in tracheostomy patients - Discover Medicine
link.springer.comBackground Airway management in tracheostomized patient is a critical aspect of clinical care, with humidification therapy playing a vital role in maintaining mucociliary clearance function. However, the mechanisms of action, influencing factors and optimization strategies of humidification therapy have not been systematically elucidated, leading to a lack of evidence-based guidance in clinical practice for selecting and adjusting humidification protocols. Objective This review aims to explore the mechanisms by which humidification therapy enhances mucociliary clearance in tracheostomized patients, evaluate its clinical efficacy and identify key factors influencing therapeutic outcomes. Ultimately, it proposes optimization strategies to improve the precision and effectiveness of airway management. Methods This narrative review was conducted by systematically searching PubMed, Scopus, Google Scholar and the Cochrane Library using keywords including “humidification therapy” “tracheostomy” “mucociliary clearance” “airway humidification” “respiratory physiological function” “clinical efficacy” “key influencing factors” and “evidence-based optimization strategies”. The search spanned English-language literature published between January 2000 and March 2025. Inclusion criteria comprised original studies, systematic reviews and clinical guidelines focusing on the mechanisms of humidification therapy in enhancing mucociliary clearance in tracheostomized patients, its clinical outcomes and comparative analyses with traditional airway management approaches. Exclusion criteria involved studies on non-tracheostomized populations, animal models or interventions lacking explicit differentiation of humidification therapy from other respiratory treatments, as well as unpublished conference abstracts and opinion-based articles. Literature selection prioritized studies elucidating mechanistic pathways of humidification therapy, empirical investigations into five core influencing fact