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Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review

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To improve the patient-centeredness of care, patient-reported outcomes have been increasingly used to quantify patients’ symptoms, function, and quali…

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Proportional Odds Model Power Calculations for Ordinal and Mixed Ordinal/Continuous Outcomes – Statistical Thinking

This article has detailed examples with complete R code for computing frequentist power for ordinal, continuous, and mixed ordinal/continuous outcomes in two-group comparisons with equal sample sizes. Mixed outcomes allow one to easily handle clinical event overrides of continuous response variables. The proportional odds model is used throughout, and care is taken to convert odds ratios to differences in medians or means to aid in understanding effect sizes. Since the Wilcoxon test is a special case of the proportional odds model, the examples also show how to tailor sample size calculations to the Wilcoxon test, at least when there are no covariates.

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