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Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure - Nature Medicine

nature.com

An analysis of exposome traits in patients with early-onset colorectal cancer (CRC) (<50 years) compared with late-onset CRC (≥70 years) based on epigenetic markers shows that pesticide usage, in particular of picloram, is associated with early-onset CRC.

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What’s Causing Colon Cancer to Rise So Fast?

Colon cancer rates in people under 50 have roughly doubled in twenty years. Nobody knows why. The incidence in the sigmoid colon nearly doubled from 1998 to 2022 in people aged 20–49, and 22% of all colorectal cancers are now diagnosed in people under 55 — twice the 11% figure from 1995, even as that age group has been

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